Original Publication Date: 8 October, 2018
Publication / Source: Bioanalysis 10(19)
Authors: Obrenovich ME, Donskey CJ, Schiefer IT et al.
Aim: Co-metabolism between a human host and the gastrointestinal microbiota generates many small phenolic molecules such as 3-hydroxy-3-(3-hydroxyphenyl) propanoic acid (3,3-HPHPA), which are reported to be elevated in schizophrenia and autism. Characterization of these chemicals, however, has been limited by analytic challenges. Methodology/results: We applied HPLC to separate and quantify over 50 analytes, including