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Well-developed ligand-binding assays demonstrate robust performance using singlet analysis


In this Research Article, published by Bioanalysis, investigators from Biogen (MA, USA) and Stat4ward LLC (PA, USA) describe their re-evaluation, in singlet, of data from five pharmacokinetic assay validations and five clinical and preclinical studies, originally run in duplicate. The results of the study confirm that well-developed ligand-binding assays (LBAs) produce comparable data whether evaluated in singlet or duplicate.

Keywords: assay validationAUCCmaxLBAMRDprecisionsingletvariance component analysis

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