In this series of short, recorded presentations the DMPK team from Waters Corporation (MA, USA) discuss fundamental and practical details regarding large molecule quantification using HRMS. These include: an introduction to peptide and protein bioanalysis, an introduction to high resolution mass spectrometry versus tandem quad mass spectrometry, an introduction to quantitative data acquisition modes on a Waters QTof and exploration of case studies in HRMS.
- Part 1: An Introduction to High Resolution Mass Spectrometry versus Tandem Quad Mass Spectrometry for Large Molecule Bioanalysis
- This presentation, presented by Ian Edwards, is designed as a primer for those new to mass spectrometry and want to apply it to large molecule bioanalysis. It also appeals to those using triple quad MS and are exploring the benefits of HRMS for quantification of challenging samples.
- Part 2: High Resolution Mass Spectrometry: Introduction to Quantitative Data Acquisition Modes on a Waters QTof for Large Molecule Bioanalysis
- Hear from Mark Wrona as he introduces and discusses data acquisition options for quantification of large molecules using high resolution mass spectrometers.
- Part 3: Case Studies in High Resolution Mass Spectrometry (HRMS) for Large Molecule Bioanalytical Quantification
- In this presentation, Caitlin Dunning demonstrates the sensitivity and selectivity that can be achieved with HRMS for the quantification of peptides and proteins, speaks to some of the practical considerations to keep in mind for successful method development and more.
- Part 4: High Resolution Mass Spectrometry for Quantification of Intact Monoclonal Antibodies in Plasma
- In this short presentation we will go over an introduction to intact level protein quantification using LC–MS, then we will cover some of the challenges and best practices associated with this application and more.
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