As part of our Spotlight on HRMS in DMPK, we carried out a survey to gain an insight into the trends, challenges and developments associated with using HRMS for DMPK studies. We would like to thank everyone who was able to share their thoughts by taking part in the survey – you can see the results below in our infographic.
Join LGC scientists in the grudge match debate direct from Cambridge (UK) to decide the new king of quantitation.
Webinar now available on demand. Absolute quantitation of intact biotherapeutics is enabled through advances in immunocapture techniques coupled to LC–MS.
This application note from Waters discusses a robust and reliable IA-LC-HRMS method for the qualitative analysis and quantification of ado-trastuzumab emtansine (T-DM1, Kadcyla™).
High-resolution mass spectrometry: an essential tool for DMPK studies of novel peptide-based modalities
In this editorial Simone Esposito (IRBM, Italy) explores how HRMS has become a well established alternative to multiple reaction monitoring for DMPK profiling and discusses the use of HRMS for DMPK studies of nove peptide-based modalities.
In this interview Joel Mathews (Ionis Pharmaceuticals Inc., CA, USA) discusses his role in the development of biomarker, PK and immunogenicity assays in the development of protein therapeutics. He explains his interest in the field and explores the use of LBA for biomarker validation
A collection of helpful answers to the most frequently asked questions concerning the use of high-resolution mass spectrometry (HRMS) in drug metabolism and pharmacokinetics (DMPK).
Complexity of human diseases should promote the use of high-resolution mass spectrometry for routine untargeted analyses
In this editorial Bertrand Rochat (University of Lausanne, Switzerland) discusses the developments in the field of HRMS over the last 2 decades and his hopes for the future use of HRMS in routine untargeted analysis.
This poster from SCIEX (Warrington, UK) reports the use of an immunoaffinity high-resolution accurate mass assay as a complimentary analytical technique for signature peptide quantification.
This presentation from SCIEX (Warrington, UK) explores why we need high-resolution accurate mass spectrometry quantification, discussing topics ranging from the desire for higher selectivity in complex matrices to the need to analyze multiple charge states and fragment ions.