As our largest feature on Bioanalysis Zone, each Spotlight explores a bioanalytical ‘hot topic’ over a 3-month period. Expect a survey, infographic, expert interview and Panel discussion, as well as additional resources from our archive.
Explore the topics we have covered so far in our curated Spotlights.
Flow cytometry continues to evolve as a cornerstone technology in bioanalysis, driven by rapid advancements in instrumentation and data analytics. The integration of high-parameter and ...
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Antibody-drug conjugates (ADCs) combine targeted monoclonal antibodies with potent cytotoxic agents. Over the last decade, the number of ADCs in drug development has been increasing. A ...
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As adeno-associated virus (AAV) therapies gain traction in the gene therapy market, the need for specialized bioanalytical support becomes increasingly critical. Bioanalysis in ...
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Bioanalysis of immunogenicity is critical for the development of therapeutic proteins, as immunogenicity can affect both the safety and efficacy of biologic drugs. High-quality ...
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The biomarker landscape is evolving at a breakneck pace, accelerated by unmet needs as well as a rapidly evolving technology landscape. This is perhaps most evident in the field of flow ...
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LBA has been considered the gold standard for bioanalytical qualitative and quantitative analysis of ADA, NAb, TAb and total ADC. It offers low-cost equipment, high throughput and ...
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Technological advancement and the discovery of various biomarkers have made personalized/precision medicine a reality. Biomarkers are measurable indicators of biological processes and ...
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Hybridization assays are readily used as bioanalytical tools to support pharmacokinetic, toxicokinetic and animal biodistribution studies for oligonucleotide drug programs. Reliable, ...
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When making pivotal decisions in support of drug development, data from ligand-binding assays (LBAs) can be difficult to manage. The robustness and reliability of the assay is directly ...
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Vaccine development is a long and intensive process requiring several testing stages. Multiple assays are required to measure candidates’ immune responses to ensure that the ...
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In recent years, cell and gene therapies have offered new and promising therapeutic modalities for the treatment of rare, inherited and acquired diseases. While both cell and gene ...
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Mass spectrometry (MS) is a powerful tool that routinely aids in the identification and quantification of the metabolites of drugs and drug candidates, and their interactions. In the ...
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A biosimilar is a subsequent version of an innovator biologic product. Biosimilars are characterized by having the same amino acid sequence as the originator therapeutic and also nearly ...
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Precision medicine involves the application of cutting-edge science to develop therapies that are tailored for patients. The approach considers individual variability in genes and ...
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During drug development, drug metabolism and pharmacokinetic (DMPK) profiles of prospective new drugs are evaluated in order to help validate toxicology studies, understand drug-drug ...
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LC–MS is a versatile method used to separate compounds based on their weight and affinity for the mobile and stationary phases of the column. Proteins and complex peptides, which are ...
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Metabolomics is defined as the identification and quantification of metabolic products in a biological system. In the past the use of this technology has aided the identification of ...
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A biomarker is a protein or small molecule indicative of homeostasis or a disease state, the concentration of which can indicate disease progression or a response to a therapeutic ...
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Chromatographic separation enables the isolation and purification of specific target compounds. It involves different separation procedures that selectively retain analytes on a solid ...
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The aim of DMPK is to enable scientists to learn the safety and efficacy of new molecular entities. HRMS is an important analytical tool used to study DMPK that continues to gain ...
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Ligand binding assays (LBA) is a key method used for the quantification of large molecules, such as proteins, antibodies and biosimilars, in pharmacokinetic (PK), toxicokinetic (TK), ...
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Flow cytometry is a versatile tool used for analyzing parameters on an individual cell basis. Originating in the 1950s, the technology measures fluorescence associated with cells, using ...
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Gene therapy is an experimental technique that involves the delivery of therapeutic nucleic acid polymers into a patient’s cells to treat or prevent a disease. Gene therapy has ...
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In order to explore the most recent developments in proteomics, this Spotlight will highlight the advances and challenges faced during method development, validation and samples ...
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The immunogenicity of biologics is a significant concern, which can affect safety and efficacy. In this Spotlight we will explore recent developments in immunogenicity, highlight key ...
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A biomarker is a protein or small molecule indicative of homeostasis or a disease state, the concentration of which can indicate disease progression or a response to a therapeutic ...
Read more In order to explore the most recent developments in large molecule quantification in regulated bioanalysis by LC–MS, this Spotlight will highlight the advances and challenges faced ...
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In order to explore the key developments and technologies in this ever-evolving field, Bioanalysis Zone will be featuring a Spotlight on the emerging technologies in DMPK and the ...
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In this Spotlight we will be exploring the recent developments and the unique challenges that oligonucleotides bring to the bioanalytical community. Oligonucleotide therapeutics ...
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In this Spotlight we explore the recent developments in the bioanalysis of biopharmaceuticals and biomarkers. As the pharma and life sciences industries continue to increase investment ...
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In last year’s Bioanalysis Zone survey on ‘Future Trends in Outsourcing’, part of a Spotlight of the same name, we asked experts with Pharma backgrounds to rank the most important ...
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Welcome to the Bioanalysis Zone Spotlight on Quantitative HRMS! HRMS has been available for a long time; originally it was applied in qualitative applications, however the introduction ...
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Welcome to the Bioanalysis Zone Spotlight on Hybrid LBA/LC-MS! LBA is historically the gold standard for biologics and is employed extensively in their analysis. LC–MS, in contrast, is ...
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Welcome to the Bioanalysis Zone Spotlight on Large molecule analysis by LC-MS! In recent years there has been an increase in large-molecule therapeutics due to their target specificity, ...
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Welcome to the Bioanalysis Zone Spotlight on Biomarkers (and biosensors)! A biomarker is “a characteristic that is objectively measured and evaluated as an indicator of normal biologic ...
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Welcome to the Bioanalysis Zone Spotlight on antibody-drug conjugates (ADCs)! ADCs are dynamic, heterogeneous mixtures typically consisting of a cytotoxic drug covalently bound to a ...
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Automation can increase throughput while maintaining quality; this increase in efficiency can lead to a reduction in the cost of bioanalysis. Along with many other benefits, automation ...
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Welcome to the Bioanalysis Zone Spotlight on Metabolomics! In recent years, metabolomics has become a ‘hot topic’ in bioanalysis; the interest in metabolomics within the bioanalytical ...
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Welcome to the Bioanalysis Zone Spotlight on Microsampling: the road ahead! There has been continued interest in microsampling both in the literature and at scientific meetings in ...
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Welcome to the Bioanalysis Zone Spotlight on ‘Hot topics in large molecule bioanalysis’! Hot on the heels of our hugely popular ‘Overcoming matrix effects’ Spotlight, Bioanalysis Zone ...
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Welcome to the Bioanalysis Zone Spotlight on Overcoming Matrix Effects! Matrix effects are a major issue for the development and validation of bioanalytical methods. Bioanalysis Zone ...
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Dried blood spots (DBS) have been one of the hottest topics in bioanalysis in recent years. The potential benefits are clear in terms of 3R principles for animal testing, cost savings, ...
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